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Updated: May 12, 2025

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在PARP抑制剂治疗期间减轻T细胞DNA损伤可以提高抗瘤疗效

Jiahao Liu1,2, Xiaofei Jiao1,2, Wei Mu3

  • 1Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Science translational medicine
|May 7, 2025
PubMed
概括

聚 ((ADP-ribose) 聚合酶抑制剂 (PARPis) 损害T细胞,降低它们的有效性. 针对T细胞中的PARP1或工程PARPi耐受性CART细胞可以通过PARPis和免疫疗法提高癌症治疗的疗效.

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