儿童Vogt-Koyanagi-Harada疾病的长期结果
Dhabiah Saeed AlQahtani1, Abeer Habeeb Almutairi2, Ibrahim Saud Ababtain3
1Vitreoretinal and Uveitis Divisions, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Ocular immunology and inflammation
|May 7, 2025
概括
儿童的Vogt-Koyanagi-Harada (VKH) 疾病可以导致良好的视觉结果,但慢性复发病例存在更严重的炎症和更高的并发症风险. 早期检测和管理对于儿童VKH患者更好的视觉预后至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 儿科医学 儿科医学
背景情况:
- 沃格特-科亚纳吉-哈拉达病 (VKH) 是一种罕见的,异常性,全身性炎症性疾病,影响富含黑色素的组织,特别是眼睛.
- 由于潜在的长期视力损伤和发育后果,儿童VKH疾病需要特别注意.
- 了解儿童的临床过程和预后因素对于优化管理策略至关重要.
研究的目的:
- 研究诊断为VKH疾病的儿科患者的临床表现,治疗结果和影响最终视力敏度的因素.
- 确定与VKH儿童视觉结果较差相关的特定特征.
- 分析儿科VKH患者队列中的长期视觉结果.
主要方法:
- 从2007年至2024年间在哈立德国王眼科医院 (KKESH) 诊断出VKH的儿科患者的人口统计和临床数据的回顾性分析.
- 对呈现视敏度,眼部炎症,并发症和最终视觉结果的评估.
- 统计分析以确定临床特征,疾病过程 (急性或慢性复发) 和最终视觉结果之间的关联.
主要成果:
- 这项研究包括69名儿童 (138只眼睛),平均年龄为12.2岁;60人患有急性VKH,9人患有慢性复发VKH.
- 患有慢性复发性VKH的儿童早些时候出现,表现出更严重的角膜和前腔炎症,以及较高的白内障,绿内障和冠状腺新血管膜 (CNVM) 发病率.
- 尽管最初的视力度平均为20/70,但最终的视力度明显改善到20/50,尽管慢性复发病例的结果不太好.
结论:
- 儿科VKH病通常能达到良好的视觉结果,但慢性复发形式与眼部炎症和并发症的增加有关.
- 在患有慢性复发性VKH的儿童中,白内障,绿内障和CNVM等眼部并发症更为普遍.
- 需要根据疾病过程量身定制的积极管理,以减轻并发症,并改善儿科VKH患者的长期视觉预后.
相关概念视频
01:30Pulmonary Hypertension: Classification and Pathogenesis
106
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
106
01:20COPD: Pathogenesis and Clinical Features
179
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
179
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:29Chronic Obstructive Pulmonary Disease-V: Management
2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
2.5K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.6K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.6K