运动,咖啡因摄入量和生物衰老之间的联合关联:对基于人口的研究进行横截面分析
Guang Chen1, Shichen Zhou1, Yunqing Xun1
1School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, PR of China.
PloS one
|May 7, 2025
概括
定期体育炼显著延缓生物衰老,观察到的好处高达特定的代谢任务等价值 (MET) 值. 咖啡因摄入量不会影响这种抗衰老作用.
科学领域:
- 老年学与公共卫生
- 运动生理学 运动生理学
- 生物遗传学 生物遗传学
背景情况:
- 老龄化是许多疾病的主要风险因素,对全球疾病负担作出了重大贡献.
- 促进健康老龄化至关重要,但有效的干预措施仍然有限.
- 世界卫生组织推的体育炼对生物衰老的影响尚未完全理解.
研究的目的:
- 研究身体活动水平 (MET分钟/周) 和咖啡因消费对生物衰老的联合影响.
- 为了确定运动强度和生物年龄标志物之间的关系.
主要方法:
- 这是从国家健康和营养检查调查 (NHANES) (2007-2020) 中对23,739名参与者的分析.
- 使用PhenoAge和ENABL Age算法对生物衰老的评估.
- 统计分析包括通用线性回归和立方线模型来评估相关性和非线性关系.
主要成果:
- 每增加100MET分钟的每周运动量与生物衰老延迟0.2年相关 (p < 0.001).
- 与超过这一值的个体相比,炼<600MET分钟/周的个体表现出加速衰老.
- 在292MET分钟 (PhenoAge) 和259MET分钟 (ENABL年龄) 以后,观察到延迟衰老的回报率下降.
- 咖啡因摄入量没有改变MET水平和生物衰老之间的关联.
结论:
- 较高的体力活动水平与延迟生物衰老有积极的关联.
- 最佳的好处是达到特定的市场经济地位门,超出此门,收益平原.
- 适当水平的体育炼是管理一般人口健康老龄化的关键策略.
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