前列腺癌患者的自杀风险:趋势,预测因子和使用SEER数据预测名ograms的发展
Feng Qi1, Yihang Xu2, Xudong Yao3
1Department of Urology, Clinical Medical College of Shanghai Tenth Hospital of Nanjing Medical University, Nanjing, China; Department of Urologic Surgery, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
概括
前列腺癌患者面临较高的自杀风险,尤其是年轻人和白人男性. 预测工具可以识别那些最容易自杀的人,使得有针对性的干预措施能够减少死亡率.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 前列腺癌 (PCa) 是一个重大的健康问题.
- 了解和减轻PCa患者的自杀风险对于综合护理至关重要.
研究的目的:
- 分析前列腺癌患者的自杀风险趋势和预测因素.
- 开发用于识别高风险个体的预测工具.
- 在PCa幸存者中为减少与自杀相关的死亡率制定策略.
主要方法:
- 对监测,流行病学和最终结果 (SEER) 数据库 (2010-2020) 的回顾性分析.
- 标准化死亡率 (SMR) 和比例死亡率 (PMR) 的计算.
- 开发和验证使用考克斯回归来预测自杀风险的预测名ograms.
主要成果:
- 前列腺癌患者的自杀SMR增加,尤其是年轻 (<55岁) 和白人患者.
- 年龄较小,白人种族和早期疾病阶段与更高的自杀比例有关.
- 年龄,种族,放射治疗和婚姻状况被确定为自杀死亡率的独立风险因素.
结论:
- 自杀是前列腺癌患者,特别是年轻,白人和未婚男性的重大,可预防的风险.
- 开发的预测工具可以帮助识别有风险的患者.
- 建议有针对性的心理社会干预措施来缓解自杀风险.
相关概念视频
Cancer Survival Analysis
301
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
301
Kaplan-Meier Approach
57
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
57
Comparing the Survival Analysis of Two or More Groups
88
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
88
Assumptions of Survival Analysis
67
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
67
Actuarial Approach
41
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
41


