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劳伦斯大湖盆地抗抑郁药度增加的生态毒理学影响,2018-2023年

Jane J Pappas¹, Natasha DesRochers², Bindu Tuteja¹

¹New Substances Assessment and Control Bureau, Health Canada, Ottawa, Ontario, Canada.

The Science of the total environment

|May 7, 2025

概括

在COVID-19大流行后,地表水中的抗抑郁药水平显著增加,原因是药物使用量增加. 这项研究测量了大湖盆地抗抑郁药及其代谢物的环境度.

科学领域:

环境化学环境化学
生态毒理学生态毒理学
制药科学制药科学

背景情况:

抗抑郁药不完全代谢,导致它们排泄到废水中.
污水处理厂的设计不是为了去除药品,允许它们进入水生环境.
包括加拿大在内的全球抗抑郁药处方在COVID-19大流行后大幅上升.

研究的目的:

为了比较COVID-19大流行爆发前后地表水中的抗抑郁药物环境度 (MECs).
调查抗抑郁药的使用量增加与环境中的抗抑郁药度之间的关系.
评估检测到的抗抑郁剂水平的潜在生态毒理影响.

主要方法:

从劳伦西亚大湖盆地67个地点收集了大约1300个水样.
开发并使用液体染色学-并联质谱法 (LC-MS/MS) 方法量化7种抗抑郁药和3种代谢物.
从IQVIA MIDAS®数据库获得了加拿大抗抑郁药销售数据 (2018-2021年).

主要成果:

在10种研究物质中,9种MEC的中位数在1.5-7.2倍的流行后显著增加 (p<0.05).
弗卢沃克萨明和10-胺三氨酸显示最大的中位数增加 (分别为4.8倍和4.7倍).
在2022年检测到的最高度是O-desmethylvenlafaxine (3113.98 ng L-1) 和venlafaxine (699.59 ng L-1),与使用增加相关.

结论:

劳伦西亚大湖盆地抗抑郁药的环境度在COVID-19大流行后大幅增加,反映了处方率的上升.
该研究强调了由于环境中测量度与已确定的生态毒理参考值的重叠导致的潜在生态毒理风险.
建议进行进一步的研究和潜在的干预措施,以减轻药品对环境的影响.

关键词:

抗抑郁药是一种抗抑郁药.在 COVID-19 疫情中,这种类型的反体是体.大湖地区的大湖.这是一个SNRI,SNRI.这是一个SSRI.表面的水是表面的水.三循环的三循环的废水处理厂的废水处理厂.

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