相关实验视频
Updated: May 12, 2025

11:13
Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
Published on: April 10, 2018
8.8K
人类和非人类灵长类动物的雌性体外游戏生殖到介质的进入:一个系统的审查
Sylwia M Czukiewska1, Celine M Roelse1, Susana M Chuva DE Sousa Lopes2
1Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.
Fertility and sterility
|May 7, 2025
概括
灵长类动物的体外体育生殖表现出进展,从干细胞中实现了介质性进入. 然而,对于人类的 oogenesis 完全复制小鼠的成功仍然是一个重大挑战.
科学领域:
- 生殖生物学 生殖生物学
- 发育生物学是发展生物学.
- 干细胞研究的研究.
背景情况:
- 试管婴儿生殖 (IVG) 提供了一个研究女性生殖线发育的模型,克服了灵长类研究中的伦理和技术问题.
- 以前的研究已经成功地在小鼠中使用IVG.成功地实现了完整的 oogenesis.
研究的目的:
- 系统地审查诱导灵长类中 meiotic 进入和进展的进展和挑战.
- 为了比较人类和非人类灵长类动物体外生育的方法和结果.
主要方法:
- 2009年至2025年间发表的23篇文章的系统审查.
- 分析报告中介细胞从多能干细胞或人类的胎儿生殖细胞进入研究,Cynomolgus子和.
主要成果:
- 据报道,从差异化的多能干细胞和灵长类动物的ex vivo培养的胎儿生殖细胞中进行了 meiotic 进入.
- 虽然取得了显著的进展,但在实现灵长类动物的完整 oogenesis 方面仍然存在挑战.
结论:
- 介质的进入是灵长类动物体外生殖过程中的关键里程碑.
- 将小鼠IVG的成功转化为灵长类动物,特别是人类应用,需要进一步的研究和开发.
相关概念视频
Meiosis I
35.3K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
35.3K
In-vitro Mutagenesis
13.6K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
13.6K
Meiosis II
181.5K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
181.5K

