关于心血管疾病风险和螺旋计轨迹的PRISm表型的比较:一项大型前性队列研究
Zihan Wang1, Jianyi Zhang2, Haoliang Cui2
1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Research Center for Chronic Airway Diseases, Peking University Health Science Center, Beijing, China.
具有限制性模式的保留比率受损螺旋计 (PRISm) 与心血管疾病 (CVD) 风险增加有关. 了解PRISM轨迹对于早期干预和缓解心脏事件至关重要.
科学领域:
- 肺部医学 肺部医学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 新出现的证据表明,保留比率受损螺旋计 (PRISm) 和心血管疾病 (CVD) 结果之间存在联系.
- PRISM表型,其进展和心血管疾病风险之间的关系需要进一步调查.
研究的目的:
- 调查基线PRISM表型与事件心血管疾病之间的关联.
- 分析PRISM表型的过渡轨迹及其对心血管疾病风险的影响.
主要方法:
- 对285,049名参与者进行基线螺旋计 (2006-2010年) 的分析.
- 排除具有先前存在心血管疾病或呼吸道阻塞的个人.
- 从23,650名参与者 (2014-2020年) 的随访螺旋计数据被用于研究肺功能过渡.
主要成果:
- 在基线限制性PRISm与非限制性PRISm相比,与心力衰竭 (HR=1.20),中风 (HR=1.05) 和整体心血管疾病 (HR=1.10) 的风险更高有关.
- 限制性PRISm表型倾向于稳定,而非限制性PRISm表型随着时间的推移显示出更多的转变.
- 与持续的正常螺旋计相比,从正常螺旋计过渡到限制性PRISM (HR=1.71) 或呼吸道阻塞 (HR=1.45) 增加了心血管疾病风险.
结论:
- 限制性PRISM显示出与非限制性PRISM相比,与事件心血管疾病的相关性更强.
- 对于PRISm表型,存在不同的螺旋测量过渡轨迹.
- 针对PRISm肺功能的早期干预可以减少心血管事件发生率.
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