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在SLE中发现NINJ1:脏和血液表现的潜在生物标志物

Muyuan Li¹, Ke Liu², Meidong Liu²

¹Department of Rheumatology, Xiangya Hospital, Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Sepsis Translational Medicine Key Lab of Hunan Province, Changsha, Hunan, China; Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Clinica chimica acta; international journal of clinical chemistry

|May 7, 2025

概括

血清NINJ1水平在患有全身性红斑狼 (SLE),一种复杂的自身免疫性疾病的患者中升高. 较高的NINJ1水平表明狼性炎和血小板衰竭,这表明NINJ1是SLE诊断和监测的潜在生物标志物.

科学领域:

免疫学免疫学免疫学
自免疫性疾病自免疫性疾病
生物标志物发现发现

背景情况:

系统性红斑狼 (SLE) 是一种自身免疫性疾病,其原因复杂且大部分未知.
确定可靠的生物标志物对于SLE诊断,预后和管理至关重要.

研究的目的:

调查SLE患者血清NINJ1蛋白水平的临床意义.
评估血清NINJ1作为SLE的诊断和预后生物标志物的潜力.

主要方法:

在99名新诊断的SLE患者和43名健康对照人群中量化了血清NINJ1水平.
统计分析检查了NINJ1水平与临床表现,炎症标志物 (CRP,NLR) 和自身抗体之间的关联.
用接收器操作特征 (ROC) 曲线分析来评估诊断准确性.

主要成果:

与健康对照人群相比,SLE患者的血清NINJ1水平显著升高 (p < 0.0001).
升的NINJ1水平在患有狼性炎 (LN) 和血小板狭窄症的SLE患者中尤为明显.
NINJ1水平与蛋白尿,C反应蛋白 (CRP) 和中性粒细胞与淋巴细胞比率 (NLR) 有正相关.
在ROC分析中,SLE中血清NINJ1的诊断性能良好 (AUC = 0.83).

结论:

血清NINJ1代表了系统性红斑狼的一个有前途的生物标志物.
NINJ1可能特别有用,用于识别患有狼性炎和血小板狭窄症的患者.
这种生物标志物可以帮助分层和监测SLE疾病活动.

关键词:

生物标志物生物标志物炎症性活动的炎症性活动.这就是NINJ1的意义.患有脏干扰的情况系统性红斑性狼红斑性狼系统性狼

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