身体症状和炎症水平与非COVID-19后抑郁症相比,具有COVID-19后抑郁症的特征
Maria Pepe1, Marco Di Nicola1, Giuseppe Mandracchia2
1Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Journal of affective disorders
|May 7, 2025
概括
在COVID-19之后的大型抑郁症通常伴有明显的身体和认知症状,并伴有较高的炎症水平. 这项研究将其与非COVID-19抑郁症区分开来,有助于有针对性的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 大型抑郁发作 (MDE) 影响大约30%的COVID-19幸存者.
- 已经提出了COVID-19后MDE的特定临床概况,包括身体,认知和免疫-炎症变化.
- 在COVID-19后的MDE和非COVID-19后的抑郁症之间进行直接比较是有限的.
研究的目的:
- 描述和比较COVID-19后MDE与非COVID-19后抑郁症患者的身体和认知症状和炎症标志物.
- 为了确定COVID-19感染后与MDE相关的特定特征.
主要方法:
- 评估了209名MDE患者的队列,分为COVID-19后和非COVID-19后的组.
- 使用汉密尔顿抑郁评分表 (HDRS),汉密尔顿焦虑评分表 (HARS),数字符号替换测试 (DSST) 和感知缺陷问卷-抑郁5项 (PDQ-D5) 评估了症状.
- 使用血清衍生的指数测量炎症水平,包括系统性免疫炎症指数.
主要成果:
- 在COVID-19后的MDE组 (46.9%) 显示出更高的首次出现抑郁症,更高的发病年龄,以及更明显的身体和认知症状 (HDRS,HARS,PDQ-D5得分).
- 在COVID-19后的MDE组中,炎症指数的升高显著更高.
- 后勤回归确定了COVID-19后MDE和身体症状以及系统性免疫炎症指数之间的显著关联,具有高的区分潜力 (AUC=0.921).
结论:
- 后COVID-19 MDE表现出一个独特的临床表现,其特点是突出的身体症状和加剧的全身炎症.
- 这些发现强调了需要精确地描述COVID-19后的抑郁症.
- 根据特定的临床和炎症概况进行个性化干预,可以提高受影响患者的功能恢复.
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