在沙特阿拉伯贾赞省最近和过去的登革热感染中的血液学参数
Abdulrahim Hakami1, Ryhanh Tomehi1, Ahmad A Irekeola1
1From the Department of Clinical Laboratory Sciences (Hakami, Alasmari, Makkawi), College of Applied Medical Sciences, King Khalid University, Abha, from the Department of Microbiology and Virology (Tomehi), Abu Arish General Hospital, from the Department of Medical Laboratory Technology (Dobie), Jazan University, from the Department of Hematology and Blood Bank (Matari), Baish General Hospital, Jazan, from the Department of Clinical Laboratory Sciences (Alshehri), College of Applied Medical Sciences; from the Health Research Center (Alshehri), Najran University, Najran, Kingdom of Saudi Arabia, from the Department of Medical Microbiology and Parasitology (Irekeola), School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, from Department of Biological Sciences (Irekeola), Microbiology Unit, College of Natural and Applied Sciences, Summit University Offa, Kwara, Nigeria, and from the Department of Biotechnology (Mohammed), College of Sciences and Technology, Omdurman Islamic University, Omdurman, Sudan.
这项研究发现,异常的血液学值,包括红细胞,血红蛋白和血红素,可能表明过去的登革热感染. 需要进一步的研究来证实这些预测标记.
科学领域:
- 医学研究 医学研究
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 登革热是全球重要的健康问题.
- 确定登革热感染的可靠标志物对于诊断和管理至关重要.
- 血液学参数在病毒感染期间通常会受到影响.
研究的目的:
- 研究血液学参数作为登革热感染的潜在预测标记.
- 分析登革热阳性个体与健康对照人群之间的血红蛋白,血红素和红细胞计数的差异.
主要方法:
- 在沙特阿拉伯,收集了146名疑似登革热患者和59名健康对照者的血液样本.
- 使用酶相关免疫吸收试验 (ELISA) 检测出抗登革热抗体.
- 测量了血液学参数,包括血红蛋白 (HGB),血红素 (HCT) 和红细胞 (RBC) 计数.
主要成果:
- 与对照组相比,登革热阳性患者的红血细胞,HGB和HCT水平较低.
- 在登革热患者中观察到显著较低的红细胞 (p=0.0022),HGB (p=0.0002) 和HCT (p<0.0001).
- 在登革热患者中观察到异常低的平均HGB (12.47g/dl) 和HCT (39.03%). 在最近和过去的感染中,HCT显著下降,而红细胞和HGB仅在过去的感染中显著下降.
结论:
- 以前的登革热感染可能导致持续的异常血液学值.
- 血液学参数显示出过去登革热暴露的潜在指标.
- 需要进一步的研究来验证这些发现并探索它们的临床实用性.
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