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不孕症激素治疗后乳腺癌发病率:基于人口的研究的元分析

Amal Y Zaman¹, Lama S Alrefai¹, Dorar F Alharbi¹

¹From the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.

Saudi medical journal

|May 7, 2025

概括

激素生育治疗不会增加女性患乳腺癌 (BC) 的风险. 这项对15项研究的元分析没有发现任何显著的关联,但由于研究异质性,结果应谨慎解释.

科学领域:

生殖内分泌学生殖内分泌学
在瘤学瘤学.
流行病学流行病学

背景情况:

不孕症影响了女性人口的很大一部分.
激素生育疗法被广泛用于解决不孕症.
人们担心与这些治疗相关的潜在的长期健康风险,包括乳腺癌 (BC).

研究的目的:

进行全面的元分析,了解激素生育药物与女性乳腺癌 (BC) 风险之间的关系.
综合现有基于人口的研究的证据,以评估生育治疗后的BC发病率.

主要方法:

从2003年到2023年,在主要数据库 (PubMed,Cochrane,Embase,Scopus,Web of Science) 进行系统的文献搜索.
包括基于人口的研究,比较接受激素生育治疗的妇女与对照组的BC发病率.
使用随机和固定效应模型进行元分析,以组合风险比率 (RRs) 和危险比率 (HRs).

主要成果:

对15项研究 (92,555名女性) 的综合分析显示,使用荷尔蒙生育药物的BC风险没有增加 (RR=1.00,95% CI: [0.97-1.02]).
在RR分析中观察到低异质性 (I2=32%);灵敏度分析证实了一致的发现.
对报告HR的4项研究的分析表明,HR具有显著的保护作用 (HR=0.91),但具有实质性的异质性 (I2=96%),表明方法上的差异.

结论:

这一元分析表明,在荷尔蒙不孕症治疗后,没有证据表明乳腺癌风险增加.
在解释结果时建议谨慎,因为在某些分析中观察到显著的异质性,特别是那些使用危险比率的分析.
普罗斯佩罗登记:CRD42024569158.8. 这是一个非常好的平台.

关键词:

乳腺癌乳腺癌乳腺癌荷尔蒙生育治疗荷尔蒙生育治疗不孕症不孕不育不孕不育不孕不育

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