用J-门系统替换过导管大动脉门的八年临床结果
Fei Li1,2, Yuetang Wang2, Donghui Xu2
1Heart Valve and Atrial Fibrillation Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
概括
J-Valve系统在跨导管大动脉置换 (TAVR) 中显示出良好的长期结果. 它表现出了出色的耐用性和血液动力学性能,特别是在纯大动脉吐 (PAR) 患者中.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 生物材料科学 生物材料科学
背景情况:
- 过导管大动脉置换 (TAVR) 是大动脉疾病的关键治疗方法.
- 特定TAVR系统的长期结果需要持续评估.
- J-Valve系统是一种具有独特植入特性的替代TAVR设备.
研究的目的:
- 通过使用J-Valve系统,评估经过跨的TAVR后的8年临床结果.
- 为了评估J-Valve的长期耐用性和血液动力学性能.
- 为了比较患有大动脉狭窄患者与纯大动脉吐患者的结果.
主要方法:
- 一组21名患者通过J-Valve系统进行了跨管TAVR.
- 对18名患者进行了系统的临床和心声回声监测,持续长达8年.
- 根据患者的诊断分析了结果:大动脉狭窄 (AS) 或纯大动脉吐 (PAR).
主要成果:
- 在8年后,全因死亡率为16.7%,没有J-Valve故障或血栓形成.
- 在50%的AS患者中发生了中度至严重的膜恶化,但没有PAR患者.
- 与AS患者不同,PAR患者的有效孔面积有所改善,左心室重塑显著,与AS患者不同.
结论:
- 在TAVR中,J-Valve系统表现出有利的8年临床结果.
- 门表现出卓越的长期耐用性和血液动力学性能,特别是在纯大动脉吐患者中.
- 这些发现支持J-Valve作为TAVR的可行选择,特别是针对特定患者的个人资料.
更多相关视频
14:14Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
Published on: December 11, 2017
13.9K
05:31Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
Published on: June 8, 2022
2.7K
相关概念视频
01:17Heart Valves
3.8K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
3.8K
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
101
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
101
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
87
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
87
01:11Clinical Trials: Overview
2.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
2.5K
01:28Esophageal Varices-II: Clinical Features and Management
27
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
27
01:15Thoracic Aorta
272
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
272