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相关概念视频

Plant Breeding and Biotechnology01:59

Plant Breeding and Biotechnology

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Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
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The Central Dogma01:20

The Central Dogma

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The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
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Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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相关实验视频

Updated: May 12, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
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工业生物技术的分子过程控制.

Chantal Treinen1, Christina Peternell1, Philipp Noll1

  • 1Cellular Agriculture, TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Strasse 4, 85354 Freising, Germany.

Trends in biotechnology
|May 7, 2025
PubMed
概括

分子过程控制通过在多个生物层面整合监管机制来增强工业生物技术. 这种方法优化生物过程的可持续性和经济竞争力,推动未来的生物技术创新.

关键词:
生物经济是生物经济.生物制造 生物制造 生物制造分子过程控制分子过程控制精密发酵精密发酵的方法议员数量检测是指对议员数量进行检测.调节性RNARNA的调节性RNA是什么

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相关实验视频

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科学领域:

  • 工业生物技术 工业生物技术
  • 生物技术工程 生物技术工程
  • 生物过程优化 生物过程优化

背景情况:

  • 可持续和经济上具有竞争力的生物技术过程是关键的挑战.
  • 传统的生物工艺设计策略在充分利用潜力方面存在局限性.
  • 在集成优化策略以实现先进的工艺设计方面存在差距.

研究的目的:

  • 审查生物技术中分子过程控制的分子机制.
  • 要突出分子过程控制如何弥合传统设计局限性.
  • 展示分子过程控制对未来生物技术进步的潜力.

主要方法:

  • 对内源性和实施的分子机制的审查.
  • 在转录,翻译和系统层面对监管控制的分析.
  • 探索分子过程控制作为一个整合工具.

主要成果:

  • 分子机制在转录,翻译和系统层面提供控制.
  • 这些机制可以是内源的,也可以是专门在生物体中设计的.
  • 分子过程控制使多层过程设计和优化成为可能.

结论:

  • 分子过程控制对于推进工业生物技术至关重要.
  • 它为增强现有生物工艺提供了一个框架.
  • 它为未来的生物技术过程设计和创新打开了新的可能性.