固体器官移植接受者与SARS-CoV-2感染的长度评估
Will Vuyk1, Max Bobholz1, Isla Emmen1
1Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.
Transplantation proceedings
|May 7, 2025
概括
40%的实体器官移植接受者在28天或更长时间内释放了SARS-CoV-2RNA,这表明免疫功能低下的个体的病毒分泌时间长. 这种持续的SARS-CoV-2感染引起了人们对潜在的变种选择的担忧.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 移植医学 移植医学 移植医学
背景情况:
- 免疫功能受损的个人,如固体器官移植 (SOT) 接受者,面临SARS-CoV-2感染严重后果的风险增加.
- 了解病毒持久性对于在SOT接受者中管理SARS-CoV-2至关重要.
研究的目的:
- 为了确定在SOT接受者中SARS-CoV-2RNA阳性的持续时间.
- 为了评估这种脆弱人群中的病毒持久性.
主要方法:
- 对最近感染SARS-CoV-2的SOT接受者进行前性研究.
- 在鼻和便样本中追踪病毒RNA分泌.
- 持续感染的定义是感染后≥28天检测到SARS-CoV-2RNA.
主要成果:
- 在30名SOT接受者中,12名 (40%) 在感染后≥28天显示SARS-CoV-2RNA阳性.
- 一名参与者在54天内有可检测的病毒RNA.
- 三名参与者在感染后的50天内检测出阳性.
结论:
- 显著比例的SOT接收者经历了长时间的SARS-CoV-2RNA脱落.
- 持续的病毒检测,即使有治疗,也突出了免疫抑制的挑战.
- 人们对新型病毒变异的潜在选择存在担忧,原因是长时间在免疫受损宿主中脱落.
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