两个伴侣的酒精消费和流产风险
Michael L Eisenberg1, Michael Scott1, Nicolas Seranio1
1Stanford University School of Medicine, Department of Urology, Stanford, California, USA.
Reproductive biomedicine online
|May 7, 2025
概括
任何父母的怀孕前的酒精消费都没有增加流产风险. 这一发现适用于各种酒精类型和消费水平,为酒精提供了清晰度.
科学领域:
- 生殖健康 生殖健康
- 围产期流行病学 围产期流行病学
- 人类繁殖人类的繁殖.
背景情况:
- 在怀孕前期饮酒是一种可修改的生活方式因素.
- 了解父母的酒精摄入量对早期怀孕结果 (如流产) 的影响,对于公共卫生指导至关重要.
- 以前的研究对酒精对流产风险的影响产生了不同的结果.
研究的目的:
- 调查母亲和父亲在怀孕前的酒精消费与随后流产风险之间的联系.
- 分析潜在的剂量反应关系以及母亲和父亲的酒精摄入量之间的差异.
主要方法:
- 潜在的队列研究 (在线妊娠研究 - PRESTO) 涉及试图怀孕的夫妇.
- 通过自我管理的社会人口统计,生活方式和酒精消费等问卷收集的数据.
- 考克斯比例危险回归模型用于估计流产风险的危险比率.
主要成果:
- 在调整了混变量后,没有观察到任何伴侣在怀孕前的酒精摄入量和流产风险增加之间存在显著的关联.
- 对于女性和男性,每周饮酒量 (0.1-6.9,7-13.9和≥14杯) 的不同水平,流产的危险比保持在接近1的水平.
- 这些发现在不同类型的酒精 (葡萄酒,烈酒,酒) 和各种人口学子组中是一致的.
结论:
- 母亲或父亲对怀孕前的酒精使用似乎不会增加流产的风险.
- 这些发现表明,适度的孕前酒精消费可能不是早期妊娠损失的重要风险因素.
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