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Updated: May 12, 2025

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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SLC6A4和HTR1A基因变异之间的相互作用可能导致抗抑郁药失败

Sandra Hanna1, Mark Faiz2, Sanjida Ahmed2

  • 1Personalized Prescribing Inc., Richmond Hill, ON, Canada. sandra@personalizedprescribing.com.

The pharmacogenomics journal
|May 7, 2025
PubMed
概括

血清素载体 (SLC6A4) 和自身受体 (HTR1A) 基因的遗传变异与抗抑郁药治疗失败有关. HTR1A rs6295 GG和SLC6A4 SS变体的组合显著增加了抑郁症和焦虑症患者SSRI不响应的风险.

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