与代谢功能障碍相关的脂肪性肝病与多种呼吸系统疾病的风险增加有关
Bofu Liu1,2, Yu Jia3, Zhihan Gu1,2
1Department of Emergency Medicine and Institute of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
Scientific reports
|May 7, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 增加了许多呼吸道疾病的风险,包括肺炎和肺癌. 管理MASLD可能有助于预防这些肺部疾病.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 肺部病理学 肺部病理学
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 人们对MASLD与各种呼吸系统疾病之间的联系仍然不完全了解.
- MASLD影响了相当一部分人口,突出了对其系统性影响的研究的需要.
研究的目的:
- 调查MASLD与发展11种不同类型的呼吸道疾病的风险之间的联系.
- 为了确定MASLD的严重程度是否会影响呼吸系统疾病的风险.
- 探索这种关联与遗传倾向的独立性.
主要方法:
- 利用了英国生物库的前景队列,包括393416名参与者.
- 采用考克斯回归分析来评估MASLD和呼吸系统疾病发病率之间的关系.
- 使用ICD-10代码识别的呼吸道疾病,并根据多种混因素进行调整.
主要成果:
- MASLD与11种研究呼吸道疾病中的9种疾病的风险增加有显著的关联.
- 具有高风险的特定疾病包括流感,肺炎,慢性下呼吸道疾病,喘和肺癌.
- 呼吸道疾病的风险随着MASLD严重程度的增加而升级,这是纤维化得分所表明的.
结论:
- MASLD是广泛的呼吸道疾病的重要危险因素.
- 观察到的关联是独立于遗传因素的,这表明有直接的病理生理联系.
- 准MASLD为呼吸道疾病的综合预防提供了一个潜在的战略.
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