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儿科喘恶化的季节性变化及其与喘表型的关联
Firdian Makrufardi1,2, Desy Rusmawatiningtyas2, Indah Kartika Murni2
1International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Pediatric research
|May 7, 2025
概括
高乙酸/中性酸 (HBE/LBN) 增加了冬季/秋季儿科喘恶化的风险. 低氨基酸/中性酸 (LBE/LBN) 在冬季,春季和夏季降低风险,表明季节性影响喘严重程度.
科学领域:
- 儿科肺病学 儿科肺病学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 儿童喘恶化受到各种因素的影响,包括季节性变化和炎症标志物.
- 了解血液炎症表型在儿科喘中的作用对于有效管理至关重要.
研究的目的:
- 研究血液炎症表型 (乙酸和中性酸) 与急性儿科喘恶化之间的关联.
- 在不同季节和COVID-19大流行期间分析这些关联.
主要方法:
- 对32,160名儿科喘患者 (2008-2021) 的回顾性研究.
- 基于乙氨基 (E) 和中性粒细胞 (N) 数量的喘血液炎症表型的分类:低 (L) 和高 (H).
- 后勤回归分析以确定喘恶化的几率比率 (OR).
主要成果:
- 增加的中性粒细胞和乙氨基粒细胞与更高的喘恶化几率相关.
- 在冬季和秋季,高胆固醇/低中性粒细胞 (HBE/LBN) 现型显示恶化风险增加 (ORs 1.232和1.248).
- 低氨基酸/低中性粒细胞 (LBE/LBN) 现型显示,冬季,春季和夏季恶化风险降低 (OR 0.873,0.872和0.813).
结论:
- HBE/LBN表型与冬季和秋季住院儿童喘恶化风险较高有关.
- LBE/LBN表型与跨越多个季节的恶化风险较低有关.
- 乙酸和中性酸水平显著影响儿科喘恶化,具有明显的季节性模式.
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