关于诊断GH缺乏症的共识和争议:GH研究协会的Delphi调查
M C Arlien-Søborg1, S Radovick2, M C S Boguszewski3
1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Pituitary
|May 7, 2025
概括
在儿童中诊断生长激素缺乏症 (GHD) 与成年人相比,对测试的共识较少. 这项研究对两年龄组GHD诊断的当前临床实践进行了映射.
科学领域:
- 内分泌学 在内分泌学.
- 儿科内分泌学 儿科内分泌学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 生物化学测试对于诊断儿童和成人生长激素缺乏 (GHD) 是至关重要的.
- 现有的GHD诊断标准和生物化学测试受到持续的辩论和争议.
- 了解当前的临床实践对于标准化GHD诊断至关重要.
研究的目的:
- 在儿科和成人群体中绘制和分析目前诊断生长激素缺乏症 (GHD) 的临床实践.
- 确定内分泌学家之间关于GHD诊断标准和方法的共识和分歧的领域.
主要方法:
- 在成长激素研究协会的成员中进行了德尔菲调查.
- 来自14个国家的儿科 (n=18) 和成人 (n=25) 内分泌学家参加了这次会议.
- 参与者通过7分利克特尺度对61个关于GHD诊断的陈述评价了他们的同意,共识被定义为≥80%的同意或不同意.
主要成果:
- 在59%的儿科陈述和88%的成人陈述上达成共识.
- 关于GHD测试的临床背景和时间存在普遍共识.
- 低于正常的IGF-I水平用于诊断胰腺垂体炎症; 特定刺激测试 (阿基因,儿童的葡萄糖; 儿童的ITT,成人的麦西莫雷林) 和GH切断值显示不同的共识.
结论:
- 诊断生长激素缺乏症 (GHD) 的临床实践共识在儿科内分泌学中低于成人内分泌学.
- 儿科GHD诊断中的差异主要与生长激素刺激测试的选择和解释有关.
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