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乳腺后辐射血管肉瘤中MMP9表达的升调:一种可能的预测性风险因素
Qingqing Ding1, Phyu P Aung1, Hongxia Sun1
1Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
概括
矩阵金属蛋白酶9 (MMP9) 可能是放射治疗后乳腺激进后辐射血管肉瘤的风险因素. 在患有这种罕见但危险的二次癌症的患者中观察到更高的MMP9表达.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 病理学 病理学 病理学
背景情况:
- 乳腺的放射后血管肉瘤是一种罕见的,但在乳腺癌的放射治疗后出现的侵袭性二次癌症.
- 矩阵金属蛋白酶9 (MMP9) 之前与癌症的发展,进展和血管生成有关.
研究的目的:
- 调查MMP9表达在乳腺后辐射血管肉瘤发展中的作用.
- 为了比较MMP9表达在辐射后患有血管肉瘤的患者与没有患有血管肉瘤的患者.
- 为了比较MMP9表达在后辐射乳腺血管瘤与非辐射相关血管瘤.
主要方法:
- 从放射治疗的乳腺癌患者手术样本中对MMP9表达的比较.
- 对乳腺血管肉瘤样本中MMP9表达的分析,这些样本来自患有后辐射血管肉瘤和非乳腺血管肉瘤的患者.
主要成果:
- MMP9在乳腺癌样本的内皮细胞中表达,这些样本来自放射后患有血管肉瘤的患者,但不是那些没有患有血管肉瘤的患者.
- 与非辐射相关的原发性血管瘤在非乳腺部位的患者相比,乳腺后辐射血管瘤患者的MMP9表达显著更高.
结论:
- 在内皮细胞中MMP9的表达可能表明患乳腺后辐射血管肉瘤的风险增加.
- MMP9似乎在乳腺后辐射血管肉瘤的发病过程中发挥着重要作用.
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