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Updated: May 12, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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5-Bromouracil-gracillin (5BrU-G) 综合体:一种APOBEC3激活的治疗策略,利用癌症特异性酶活性进行选择性细胞毒性

Mays S Hatim1, Ali Z Al-Saffar2, Mohammad Abdul Wahab Shaker Al-Aadhami3

  • 1Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq.

Medical oncology (Northwood, London, England)
|May 7, 2025
PubMed
概括

这项研究引入了一种新型智能药物,使用格拉西林和5-甲,由正常的淋巴细胞携带. 它通过APOBEC3酶活性选择性地向癌细胞,最大限度地减少对健康组织的损害.

关键词:
5 - - 甲基甲基的使用.在 APOBEC3 中,APOBEC3 是基因毒性 基因毒性格拉西林 (Gracillin) 是一种葡萄素.分子对接是分子对接.

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Published on: March 8, 2018

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A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity11:13

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

Published on: July 12, 2018

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