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在静脉内注射抗VEGF注射后,导致眼内压力短期升高的因素
Yanchen Liu1, Ting Wang2, Xiaohong Zhang3
1Department of Ophthalmology, Yidu Central Hospital of Weifang, Weifang, 262500, China.
BMC ophthalmology
|May 7, 2025
概括
在抗VEGF注射后短期内眼压 (IOP) 升高与年龄较大,具有自然透镜和糖尿病有关. 识别这些危险因素有助于预测和管理患者的手术后IOP峰值.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 对抗VEGF药物的静脉内注射 (IVI) 可以导致短期内眼压 (IOP) 升高.
- 这种IOP峰值对视网膜健康构成潜在风险.
- 了解内压升高的预测因素对于患者管理至关重要.
研究的目的:
- 确定影响短期内血压升高的关键因素,后抗VEGF IVI.
- 为预测和管理术后IOP升高提供见解.
- 为临床实践提供有关患者风险分层的信息.
主要方法:
- 对接受抗VEGF IVI.IVI治疗的患者的64个术后测量结果的观察性研究.
- 收集的数据包括患者的人口统计,临床特征 (透镜状况,糖尿病) 和IOP.
- 一个线性混合效应模型分析了与注射后5分钟内脉压升高相关的因素.
主要成果:
- 平均基线内血压为14.64mmHg,注射后5分钟达到43.33mmHg的峰值.
- 注射后30分钟内心压力下降到19.25mmHg,其中68.8%≤21mmHg.
- 老年,本地晶状透镜和糖尿病是5分钟内血压升高的重要预测因素 (分别为p<0.001,p<0.001,p=0.009).
结论:
- 抗VEGF IVI治疗后短期内血压升高与年龄较大,本地晶状透镜的存在和糖尿病显著相关.
- 这些因素可以帮助识别高风险患者.
- 对于高风险个体,建议采用个性化预防策略,以减轻IOP升高风险.
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