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与雌激素相关的受体β替代拼接异型在食道状细胞癌中的表达和预后价值

Kai-Yuan Jiang^1,2, Jia-Xin Wan², Hong-Yun Li¹

¹Department of Cardiothoracic Intensive Care Unit, Affiliated Hospital of North Sichuan Medical College, No.1, Maoyuan South Road, Shunqing District, Nanchong, 637000, China.

European journal of medical research

|May 7, 2025

概括

这项研究表明,与雌激素相关受体β-sf (ERRβsf) 与ERRβ的高比率与食道状细胞癌 (ESCC) 患者的更好的生存率有关. 这些ERRβ替代拼接异型表现为ESCC的预后生物标志物具有前途.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

与雌激素相关受体β (ERRβ) 的替代拼接异型,包括ERRβsf,ERRβ2和ERRβΔ10,都与各种癌症有关.
这些异构体在食道状细胞癌 (ESCC) 发病过程中的特定作用尚不清楚.

研究的目的:

研究ESCC中的ERRβ替代拼接异型的表达水平.
为了确定ESCC患者中这些异构体的预后价值.

主要方法:

来自54名患者的ESCC和配对正常组织的前景采集.
西方斑分析用于量化ERRβ异型的蛋白质表达.
卡普兰-梅尔和考克斯回归分析以评估整体存活率和预后因素.

主要成果:

与正常组织相比,ESCC组织中的ERRβsf/ERRβ比率显著高于正常组织 (P=0.017).
患有高ERRβsf/ERRβ比率的患者的整体存活率显著改善 (77.1%与50.8%,P=0.024).
高ERRβsf/ERRβ比率 (HR=0.219) 和N阶段 (HR=7.892) 被确定为独立的预后因素.

结论:

这项研究是首次报告ESCC中的ERRβ替代拼接异型.
高ERRβsf/ERRβ比率与ESCC的良好预后有关.
ERRβ替代拼接异型可以作为ESCC的有价值的预后生物标志物.

关键词:

另一个替代拼接.食管状细胞癌的癌症与雌激素相关的受体β.预测预后预测预测

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