焦虑和小肠细菌过度生长:与反复复发的胃口有关联
Zijian Liu1,2, Mingxing Lu1,3, Wei Wang4
1Department of Oral Medicine, National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, No. 22 Zhongguancun Avenue South, Haidian District, Beijing, 100081, P.R. China.
复发性口腔 (RAU) 患者表现出更高的焦虑和肠道失调率. 这些因素,包括小肠细菌过度生长 (SIBO),可能会加剧RAU的严重程度,突出显示大脑-肠轴连接.
科学领域:
- 口腔医学是指口腔医学.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 复发性口腔 (RAU) 是一种常见的口腔疾病,病因不明.
- 之前对RAU焦虑和抑郁症的研究已经产生了相互矛盾的结果.
- 肠道疾病表明肠道微生物群在RAU的发病过程中可能发挥作用.
研究的目的:
- 调查RAU与心理因素之间的相关性.
- 探索RAU和肠道微生物群失调之间的关系.
- 确定影响RAU严重程度的因素.
主要方法:
- 使用Zung的自我评价焦虑量表 (SAS),Zung的自我评价抑郁量表 (SDS) 和匹兹堡睡眠质量指数 (PSQI) 评估心理状态.
- 使用乳糖甲呼吸试验检测到小肠细菌过度生长 (SIBO).
- 按每月数量量化RAU严重程度,并将RAU患者与健康对照进行比较.
主要成果:
- 与对照组相比,RAU患者的SAS得分和SIBO阳性显著更高.
- RAU的严重程度与SAS相关,焦虑症状,SDS,PSQI得分和SIBO阳性.
- 焦虑和SIBO被确定为RAU严重程度的潜在影响因素;SAS和SDS得分与SIBO相关.
结论:
- RAU患者面临焦虑和肠道失调症的风险增加.
- 焦虑和肠道失调可能会加剧RAU的严重程度.
- 需要进一步研究RAU病变的脑肠轴.
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