遗传和环境对青春期和年轻成年期表观遗传衰老的贡献
Dmitry V Kuznetsov1,2, Yixuan Liu3, Alicia M Schowe4,5
1Bielefeld University, Bielefeld, Germany. dmitry.kuznetsov@uni-bielefeld.de.
Clinical epigenetics
|May 7, 2025
概括
独特的环境因素在过渡到成年期期间驱动表观遗传衰老变异. 遗传因素也有所贡献,其影响随着年龄的增长而增加,突出了自然和培养在生物衰老中的复杂相互作用.
科学领域:
- 遗传学和表观遗传学
- 发育生物学 发展生物学
- 衰老研究研究 衰老研究
背景情况:
- 表观遗传衰老估计器追踪生物和时间衰老,受遗传学和环境的影响.
- 表观遗传衰老的变异性在青春期增加,并在成年时稳定.
- 遗传与环境因素对这种变异的具体贡献仍然不清楚.
研究的目的:
- 研究从青春期过渡到成年期期间对表观遗传衰老变异的遗传和环境贡献.
- 分析这些贡献在不同发展阶段如何变化.
- 为了在四种不同的表观遗传衰老估计器中比较这些模式.
主要方法:
- 双胞胎建模分析了来自976名双胞胎的唾液样本,分为四个年龄组.
- 测量是在两个时间点进行的,距离大约2.5年.
- 对四种表观遗传衰老估计器的分析:Horvath加速,PedBE加速,GrimAge加速和DunedinPACE.
主要成果:
- 独特的环境因素占表观遗传衰老差异的50-68%.
- 遗传因素解释了24-47%的差异,环境因素占26-47%的差异.
- 对于一些估计者来说,个人独特的环境差异随着年龄的增长而下降,而对于成人培训的估计者来说,遗传贡献可能会增加.
结论:
- 过渡到成年期的特点是增加表观遗传衰老变异.
- 环境和遗传因素在这种发展趋势中起着重要作用.
- 表观遗传衰老估计器的设计会影响遗传和环境贡献的观察比例.
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