perflutren 脂质微球用于回声心电图对比度:一种非由 PEG 引起的过敏反应的临床病例
Chloe Wang1,2, Jackie Campbell2, Harriet Lea-Banks3,4
1Faculty of Science and Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
概括
对超声波对比剂Definity®的过敏反应可能是由于非聚乙烯糖醇 (PEG) 成分. 过敏测试证实Definity®是原因,而不是PEG,这表明是一种新的过敏反应.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 放射学 放射学是指放射学
- 药理学 药理学是指药理学的学科.
背景情况:
- perflutren 脂质微球悬浮液 (Definity®) 是一种超声波对比剂,由八烯气体,脂和PEGylated 脂组成.
- 对Definity®的过敏反应很少见,之前的报道表明聚乙烯糖醇 (PEG) 是潜在的过敏原.
- 本报告详细介绍了一个病例,其中过敏反应可能是由Definity®的非PEGylated成分引起的.
研究的目的:
- 要向Definity®报告一种新的过敏反应病例.
- 在接受Definity®的患者中调查过敏反应的致病因子.
- 要区分PEG介导和非PEG介导的对Definity®的过敏.
主要方法:
- 一名54岁的女性在心声图期间经历了Definity®注射后的过敏反应.
- 过敏测试包括对Definity®和各种含PEG物质的皮肤内测试,以及对PEG的皮肤刺伤测试和口服挑战.
- 治疗包括标准的过敏反应管理,包括迪芬胺,上腺素,皮质类固醇和丹塞.
主要成果:
- 患者在注射Definity®后15分钟内出现过敏反应.
- 过敏测试对含有PEG的物质呈阴性,但通过皮内测试对Definity®呈阳性.
- 症状通过适当的医疗治疗得到缓解.
结论:
- 这一案例突出了以前未经证实的对Definity®的过敏反应原因,与PEG无关.
- 怀疑该反应是IgE介导的反应或与非PEGylated成分的补充激活相关的伪过敏.
- 医生应该意识到对Definity®的潜在非PEG相关的过敏反应.
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