估计的T得分与Hologic使用NatIve与高加索数据在IndiAns (ETHNICA):一个单一中心的回顾性研究
Narayanan Kandasamy1, Sri Lasya Karjala2, Divyalakshmi Jayakumar3
1Department of Endocrinology, Apollo Hospitals, Greams road, Chennai, 600006, Tamil Nadu, India.
BMC musculoskeletal disorders
|May 7, 2025
概括
使用印度骨矿物密度 (BMD) 扫描的参考数据显著减少了印度骨质疏松症的过度诊断. 这凸显了在诊断骨密度状况时需要区域标准的必要性.
科学领域:
- 骨质疏松症的研究研究.
- 骨矿物质密度 (BMD) 评估评估
- 医学诊断 医学诊断 医学诊断
背景情况:
- 双能X射线吸收计 (DXA) 是测量BMD的黄金标准.
- 目前的T-score生成依赖于高加索参考数据 (NHANES-III).
- 骨质疏松症的误诊 骨质疏松症的误诊可能导致骨质疏松症的种族变异.
研究的目的:
- 使用标准高加索数据的机器生成T-score (Tstd) 与使用印度参考数据 (TICMR) 计算的T-score进行比较.
- 评估使用印度医学研究理事会 (ICMR) BMD数据对印度骨质疏松症诊断的影响.
主要方法:
- 对1144个DXA扫描 (Hologic®) 的回顾性分析,包括3420个BMD测量.
- 用性别特异性ICMR BMD数据计算的Tstd得分与TICMR得分的比较.
- 分析BMD参考数据集中的年龄和性别差异.
主要成果:
- 骨质疏松症的患病率与ICMR数据相比显著降低 (男性:16.8%至7.1%;女性:26.6%至18%).
- 在ICMR数据 (男性:59.5%至76.1%;女性:41.2%至59.6%) 中观察到正常的BMD分类的较大增加.
结论:
- 标准的高加索BMD参考数据导致印度骨质疏松症和骨质疏松症的过度诊断.
- 建议采用代表性的区域参考标准来准确诊断.
- 利用ICMR数据提高了印度人口的诊断准确度.
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