与ATZ + BEV治疗相关的不良事件的多学科干预:一个病例报告
Ko Masaki1, Motoyasu Miyzaki2, Kota Mashima3
1Department of Pharmacy, Fukuoka University Hospital, 7-45-1 Nanakuma, Jounan, Fukuoka, 814-0180, Japan. masakikou@fukuoka-u.ac.jp.
概括
针对肝癌的阿特佐利祖马布加贝瓦齐祖马布治疗可能会导致外围神经病变. 这一案例凸显了管理这种与免疫相关的不良事件的挑战,强调了为更好的患者结果提供多学科护理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 阿特佐利祖马布 (ATZ) 加贝瓦齐祖马布 (BEV) 已被批准用于不可切除的肝细胞癌.
- 免疫相关的不良事件 (irAEs),包括外围神经病变,是潜在的副作用.
- 本报告详细介绍了一种多学科的方法来管理外围神经病变作为一个irAE.
研究的目的:
- 描述一个对ATZ+BEV治疗次要的外围神经病变病例.
- 为了说明这个irAE的管理挑战和结果.
- 强调多学科干预的重要性.
主要方法:
- 一名患有肝细胞癌的60岁男性接受了ATZ+BEV.
- 高血压通过调整阿姆洛迪平和阿齐尔沙坦的剂量来控制.
- 周围神经病变被用普雷迪诺,甲基普雷迪诺和静脉注射免疫球蛋白治疗.
- 启动康复治疗并根据患者的进展进行调整.
主要成果:
- 尽管接受了最初的治疗,但患者患上了3级外围神经病变.
- 包括类固醇和IVIg在内的传统疗法显示出有限的疗效.
- 康复治疗导致功能改善,使人们能够用拐杖行走.
结论:
- 作为ATZ+BEV的irrAE,外围神经病变带来了管理困难.
- 由irAE引起的神经病变的病理生理学需要进一步研究.
- 多学科护理,早期检测和及时干预对于管理IRE至关重要.
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