新型交叉养的人体肠道微生物将托代谢成英多尔-3- propionate
Janina N Zünd1, Denisa Mujezinovic1, Markus Reichlin1
1Laboratory of Food Biotechnology, Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland.
Gut microbes
|May 8, 2025
概括
食纤维,特别是点,可以促进肠道细菌的英多尔-3-酸 (IPA) 生产. 这项研究确定了Lachnospira eligens和Enterocloster aldenensis作为IPA合成新型交叉养机制的关键参与者.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 饮食干预措施 饮食干预措施
背景情况:
- 三衍生型的醇,如醇-3-酸 (IPA),对肠道健康至关重要.
- 低IPA水平与炎症性肠病,2型糖尿病和结直肠癌有关.
- 已知饮食纤维摄入量可以增强IPA的产生.
研究的目的:
- 调查纤维对肠道微生物群IPA产生的特定影响.
- 为了确定负责IPA合成的特定细菌种群.
- 探索饮食纤维影响的IPA生产背后的机制.
主要方法:
- 从健康的成年人中培养便微生物群,用各种食纤维和托芬.
- 分析微生物社区的转变,使用16S rRNA基因安普利康测序.
- 通过有针对性的液体染色学与二极管阵列检测量取取托衍生的醇.
主要成果:
- 印产量是供体特异性的,在一些个体中,pectin显著增加了IPA.
- IPA的产量与*Lachnospira eligens*有关,这是一种利用乳清素的物种,该物种在实验室*中*生产了IPA前体的英多尔-3-乳酸盐 (ILA).
- 一个新的IPA生产者, *Enterocloster aldenensis*,被确定,专门将ILA转换为IPA;共同培养*L. eligens*和*E. aldenensis*产生了IPA,这表明了交叉养机制.
结论:
- 饮食干预措施,特别是像pectin这样的纤维摄入量,可以调节肠道微生物群的组成和代谢物生产.
- 涉及*L. eligens*和*E. aldenensis*的新型交叉养途径有助于IPA合成.
- 有针对性的饮食策略有可能促进有益的肠道细菌及其代谢物,如IPA,以改善健康.
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