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Updated: May 12, 2025

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在AL氨基粉症中对小纤维神经病变进行前性研究

Chrysanthi Bountziouka1, Despina Fotiou2, Foteini Theodorakakou2

  • 1First Department of Neurology, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
|May 8, 2025
PubMed
概括

小纤维神经病变 (SFN) 影响大多数AL氨基粉症患者,并与较差的生存率有关. 早期的多参数神经评估对于评估这些患者的预后至关重要.

关键词:
在AL氨基粉症症.在QST中,QST是QST.皮肤活检皮肤活检小纤维神经病变 小纤维神经病变生存预后 预后 生存预后

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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