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Updated: Jul 15, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

9.5K

塞鲁伦林部分纠正了亨廷顿病中发展性转录基因签名中断的状中等脊髓神经元

Carlos Galicia Aguirre1,2, Kizito-Tshitoko Tshilenge1, Elena Battistoni1

  • 1The Buck Institute for Research on Aging, Novato, California, 94945, USA.

Stem cells (Dayton, Ohio)
|May 8, 2025
PubMed
概括

亨廷顿病 (HD) 通过降低关键基因的调节来破坏中等脊髓神经元 (MSN) 的发展. 研究人员确定了小分子,如Cerulenin,这可能会逆转这些HD模型的发育变化.

关键词:
亨廷顿病就是亨廷顿病.发展发展发展发展发展.诱导多能干细胞的诱导干细胞.中等的刺状神经元.神经退行症的神经退行症一个单细胞RNAseqqq.

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Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy11:22

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

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Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System10:52

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

Published on: December 10, 2021

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相关概念视频

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...