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在大肠炎模型中,大吉素对瘤愈合的影响
Başar Can Turgut1, Muge Yurdacan Sahin2, Ozan Akıncı3
1Department of General Surgery, Istanbul Traning and Research Hospital, Istanbul-Türkiye.
概括
豆类异黄Daidzein在老鼠中没有改善结肠瘤的愈合,即使存在大肠炎. 这项研究发现,当大吉素被施用时,对静脉愈合或氧化应激标志物没有任何益处.
科学领域:
- 胃肠病学 胃肠病学
- 手术研究的研究.
- 药理学 药理学是指药理学的学科.
背景情况:
- 研究大豆异黄中的一种 - - 戴兹的治疗潜力,以增强结肠瘤治疗.
- 利用小鼠实验性结肠炎模型来模拟影响手术修复的炎症状况.
研究的目的:
- 评价肠道注射大吉素对大鼠结肠瘤治疗的影响.
- 为了确定大吉素是否影响关键的治疗参数,如氧水平,静脉突破压力和氧化应激标志物.
主要方法:
- 48只雄性Wistar白色老鼠通过直肠乙酸给药或接受水来诱导大肠炎.
- 所有老鼠都通过手术创建了结肠瘤.
- 戴兹是口服给特定组的,在术后第3天和第7天进行了分析.
主要成果:
- 在有或没有大肠炎的老鼠中,肠道戴兹并没有积极影响门愈合,氧水平或突发压力.
- 戴兹未能降低氧化应激标志物,包括谷氨过氧化酶和超氧化物脱酶.
- 在晚期术后期,在非结肠炎组中,观察到戴兹对病理损伤得分产生轻微的有益影响.
结论:
- 在大肠炎或无大肠炎的条件下,戴兹的使用没有对结肠异位瘤愈合产生积极影响.
- 结果表明,在这个实验模型中,戴兹在促进结肠外科愈合方面没有效果.
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