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Updated: Jun 13, 2025

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一个多中心,前性,观察性研究,针对晚期胃癌 (NIVO RETURNS) 的nivolumab再给药

Hiroyuki Kodama1,2,3, Yukiya Narita3, Michio Nakamura4

  • 1Cancer Chemotherapy Center, Osaka Medical and Pharmaceutical University, Osaka, Japan.

Future oncology (London, England)
|May 8, 2025
PubMed
概括

重新服用尼沃卢马布可能有利于先前接受免疫检查点抑制剂治疗的晚期胃癌患者. 这项研究研究了对初始抗PD-1/PD-L1治疗不耐药的患者的nivolumab重复治疗的疗效和安全性.

关键词:
胃癌是什么?胃癌是什么?反编程细胞死亡-1抗体.免疫检查点抑制剂免疫检查点抑制剂这就是尼沃卢马布 (nivolumab).重新管理的重复管理

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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