在患有高血压的年轻成年人中,与药物坚持相关的因素
Eunji Kim1,2, Hyeok-Hee Lee3,4,5, Eun-Jin Kim3,4
1Department of Preventive Medicine, Gachon University College of Medicine, Incheon, Republic of Korea.
Clinical hypertension
|May 8, 2025
概括
年轻人对高血压药物的坚持程度较低. 诸如男性性别,更高的收入和初始单片药物组合疗法等因素改善了坚持,这需要进一步研究.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 对抗高血压药物的不良坚持是年轻患者控制血压的主要障碍.
- 识别影响药物坚持的因素对于改善这一群体的治疗结果至关重要.
研究的目的:
- 确定与被诊断患有高血压的年轻成年人抗高血压药物坚持相关的因素.
- 分析与药物坚持相关的人口,生活方式和临床变量.
主要方法:
- 利用韩国国家医疗保险服务数据库,包括141,132名年龄在20-39岁的参与者开始服用抗高血压药物.
- 根据覆盖日数比例 (PDC) 进行分类的坚持,在第一年内良好坚持≥0.8,不良坚持<0.8.
- 采用后勤回归分析来调查各种因素与良好的药物坚持之间的关联.
主要成果:
- 只有43.3%的年轻人表现出对抗高血压药物的良好坚持.
- 与良好的坚持相关的因素包括男性性别,年龄较大,收入较高,城市居住,不吸烟和增加体力活动.
- 初始单片药物组合疗法 (OR,1.12) 和特定单片疗法,如宁-血管素阻断剂 (OR,5.24) 或通道阻断剂 (OR,4.07) 与初始利尿剂相比,与更好的坚持有关.
结论:
- 尽管坚持不良,但特定的人口和临床因素与年轻成年人改善抗高血压治疗的坚持有关.
- 最初的单片药物联合治疗可能会提高年轻高血压患者的坚持,因此需要进一步研究其长期临床影响.
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