剂量计算精度对强度调制质子疗法逆线性能量转移优化的影响
Mei Chen1,2, Wenhua Cao2, Pablo Yepes2,3
1Department of Radiation Oncology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Precision radiation oncology
|May 8, 2025
概括
精确的剂量计算对于强度调制质子疗法 (IMPT) 的优化至关重要. 在IMPT中增加光束数量并不能提高随着剂量计算算法的变化而提高计划的稳定性.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 计算生物学 计算生物学
背景情况:
- 强度调节质子疗法 (IMPT) 提供精确的剂量递送.
- 准确的剂量计算对于IMPT中的强有力的治疗计划至关重要.
- 在IMPT中优化线性能量传输 (LET) 需要高准确度的剂量计算.
研究的目的:
- 评估剂量计算精度对IMPT逆LET优化的影响.
- 评估增加光束数量是否能提高IMPT计划在不同剂量计算引擎中的稳定性.
主要方法:
- 两组IMPT计划 (DoseOpt和LETOpt) 为10名前列腺癌患者生成,使用2,4,6和9束.
- DoseOpt计划使用笔束 (PB) 算法; LETOpt计划使用蒙特卡洛 (MC) 算法与LET约束.
- 使用替代算法 (MC用于DoseOpt,PB用于LETOpt) 进行交叉计算,以比较剂量指数.
主要成果:
- 对于DoseOpt计划,PB和MC算法之间的剂量差异是最小的.
- LETOpt计划显示了显著的剂量差异 (高达CTV的D2的15.85%) 和膀剂量的11.42 Gy差异.
- 增加光束数量减少了目标覆盖范围的差异,但增加了关键结构的D2中的错误.
结论:
- 在IMPT中LET的高调节需要在优化和最终剂量计算期间精确的剂量计算.
- 添加更多的光束并不能提高IMPT计划的稳定性,以应对剂量计算算法的变化.
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