晶体结构和赫什菲尔德对凯托洛拉克甲胺的表面分析
Anna M Shaposhnyk1, Vitalii V Rudiuk2, Vyacheslav N Baumer1
1Institute of Functional Materials Chemistry SSI 'Institute for Single Crystals' NAS of Ukraine 60 Nauky Ave Kharkiv 61001 Ukraine.
概括
单晶和粉末X射线衍射揭示了凯托洛拉克甲胺的晶体结构. 键连接了阴离子和阴离子,形成了晶格中的二周期层.
科学领域:
- 晶体学 晶体学是指结晶学.
- 固态化学 固态化学
- 制药科学 制药科学 制药科学
背景情况:
- 凯托洛拉克甲胺是一种非类固醇抗炎药物 (NSAID).
- 了解其晶体结构对于配方和稳定性至关重要.
- 以前的结构研究可能是有限的.
研究的目的:
- 为了阐明 ketorolac tromethamine 的晶体结构.
- 为了研究晶格内部的分子间相互作用.
- 描述结网络的特征.
主要方法:
- 单晶X射线 difraktion 的使用方法.
- 粉末X射线衍射的粉末X射线.
主要成果:
- 不对称的单元包含一个凯托洛拉克离子和一个甲胺离子.
- 确定了N-HO和O-HO的键.
- 这些相互作用导致 (100) 晶体平面中形成一个二周期层.
结论:
- 已经确定了凯托洛拉克甲胺的晶体结构.
- 结合在组织晶体结构方面发挥着重要作用.
- 这些发现为这种NSAID的固态行为提供了洞察力.
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