与NSAID相关的小肠出血的药监测分析
Ying-Han Deng1, Meiting Jiang1, Yun Chen1
1Department of Gastroenterology, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, China.
Therapeutic advances in drug safety
|May 8, 2025
概括
与非类固醇抗炎药物 (NSAID) 相关的小肠道出血风险不会被质子抑制剂 (PPI) 显著改变. 然而,rebamipide和益生菌可能会提供保护,老年人和男性患阿司匹林诱导出血的风险更高.
科学领域:
- 药物监督 药物监督 药物监督
- 胃肠病学 胃肠病学
- 药品安全 药品安全
背景情况:
- 影响非类固醇抗炎药物 (NSAIDs) 小肠出血的因素尚未完全理解.
- 无 NSAID 诱导的肠病仍然是一个重要的临床问题.
研究的目的:
- 用药监督数据评估与NSAID相关的小肠出血.
- 为了评估同时服用药物的对NSAID诱导的小肠出血的影响.
- 为临床实践提供有关NSAID安全性的见解.
主要方法:
- 来自FDA FAERS和日本JADER数据库 (2004-2023) 的NSAID相关小肠出血数据的回顾性分析.
- 使用报告几率比率 (ROR) 来检测不良反应信号.
- 采用了奇平方测试来比较药物组合风险.
主要成果:
- 多种NSAID与小肠道出血有关.
- 质子抑制剂 (PPI) 在FAERS中没有显著改变NSAID相关的小肠出血风险.
- 在JADER中,雷巴米皮德和益生菌显示NSAID相关小肠出血的风险降低.
- 老年人和男性表现出阿司匹林相关小肠出血的风险信号增加.
结论:
- 质子抑制剂 (PPI) 似乎没有显著影响NSAID相关的小肠出血.
- 雷巴米皮德和益生菌可能对NSAID诱导的小肠出血有保护作用.
- 年龄和性别被确定为阿司匹林相关小肠出血的危险因素,特别是在老年男性中.
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