在神经性自身免疫性疾病中认知障碍的性别差异:系统性审查
Rahma Ouled Toumi1, Chalachew Kassaw1,2, Valeriia Demareva1
1Department of Cyberpsychology, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Frontiers in neurology
|May 8, 2025
概括
神经性自身免疫性疾病 (NADs) 经常导致认知障碍 (CI),女性受影响不成比例. 与NAD相关的CI中性别差异的研究有限,需要量身定制的临床方法.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 神经性自身免疫性疾病 (NAD) 经常与认知障碍 (CI) 一起发生.
- 女性更容易患上自身免疫性疾病,可能会出现明显的CI模式.
- 了解NAD中CI的基于性别的差异对于有效管理至关重要.
研究的目的:
- 审查有关特定NAD的基于性别的认知缺陷的现有文献.
- 为了确定各种神经系统自身免疫性疾病中CI的性别差异的研究差距.
- 探索这些差异的潜在机制和临床影响.
主要方法:
- 系统地在PubMed和Cochrane图书馆的文献中搜索过去十年的文章.
- 包括与认知障碍,性别差异和特定的NAD相关的关键词.
- 手动搜索灰色文献和已知的相关研究,然后对14篇选定的文章进行分析.
主要成果:
- 关于大多数NAD中CI的性别差异存在显著的研究差距,多发性硬化症 (MS) 是一个显著的例外.
- 现有证据表明,CI表现和严重程度因性别而异.
- 大多数NAD在性别特异性认知影响方面仍未得到充分研究.
结论:
- 在NAD中认知障碍,特别是性别差异,未得到充分研究,导致过度概括的结论.
- 综合性认知评估必须纳入性别差异,以准确诊断和治疗.
- 未来的研究和临床实践应侧重于精密医学,跨学科的合作,以及对NADs的个性化护理.
相关概念视频
Language and Cognition
293
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
293
Alzheimer's Disease: Overview
323
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
323
Disorders of the Nervous Tissue
945
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises...
945
Dementia
70
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
70
Autoimmune Disorders
320
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
320


