用机器人运动平台模拟大量点扫描辐射场进行质子FLASH临床前研究
Fada Guan1, Dadi Jiang2, Xiaochun Wang1
1Department of Radiation Physics The University of Texas MD Anderson Cancer Center Houston Texas USA.
Precision radiation oncology
|May 8, 2025
概括
开发了一个机器人平台,以扩大辐射场大小,用于对生物样品的质子FLASH (五秒到微秒) 辐射. 这一创新使得使用高剂量率质子疗法进行更大规模的临床前研究成为可能.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 生物物理学的生物物理.
背景情况:
- 一个质子束线以前被委托用于FLASH和小型生物样本的常规剂量率辐射.
- 增加有效的辐射场大小对于扩大临床前研究能力至关重要.
研究的目的:
- 开发和验证机器人运动平台战略,以增加质子束线的有效辐射场大小.
- 为了使更大的样本区域能够在使用质子FLASH治疗的临床前研究中被辐射.
主要方法:
- 一个定制的机器人运动平台被设计为自动移动生物样本 (细胞培养,有机体,小鼠).
- 质子束使用散射器扩大,并用黄铜聚合器塑形.
- 实施了G码运动模式,并为96孔板和小鼠设置了特定的点间距.
- 使用激光系统验证了目标定位的准确性,用EBT-XD膜验证了剂量递送.
主要成果:
- 机器人平台成功地增加了辐射细胞培养 (7毫米圆) 和小鼠 (1厘米2平方) 的有效场面大小.
- 片测量剂量概况与蒙特卡洛计算 (一维马传递率>95%) 有很好的一致性.
- 获得的FLASH剂量率为细胞/器官辐射的113.7 Gy/s和小鼠辐射的191.3 Gy/s.
结论:
- 开发的机器人平台有效地增加了临床前质子FLASH实验的场面大小.
- 这一战略提高了利用高剂量率质子辐射进行大规模生物研究的能力.
- 该系统为各种样本类型展示了精确的剂量传递和定位.
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