扩散张力成像分析沿周周血管空间 (DTI-ALPS) 在正常压力水脑症:最近进展的审查
Sonali Vij1, Carson Brooks1, April Pivonka1
1Neurosciences, Cooper Medical School of Rowan University, Camden, USA.
Cureus
|May 8, 2025
概括
在周血管空间 (DTI-ALPS) 沿线的扩散张力成像分析显示,在正常压力脑症 (NPH) 患者中,较低的值. 这种成像标记可能有助于诊断NPH并预测结果.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 脑脊液动力学 脑脊液动力学
背景情况:
- 淋巴功能障碍与神经退行性疾病有关.
- 正常压力头症 (NPH) 的发病可能涉及淋巴管功能障碍.
- 先进的MRI技术用于评估淋巴功能.
研究的目的:
- 审查关于扩散张力图像分析沿周周血管空间 (DTI-ALPS) 指数和NPH之间的关联的研究.
- 评估DTI-ALPS作为NPH的诊断和预后工具.
主要方法:
- 对在NPH中调查DTI-ALPS的研究进行系统审查.
- 对NPH患者与对照患者的DTI-ALPS指数值的分析.
- DTI-ALPS与其他NPH成像标志物和临床结果的相关性.
主要成果:
- 与健康对照组相比,NPH患者的DTI-ALPS指数值较低.
- DTI-ALPS指数与已建立的NPH成像生物标志物相关.
- DTI-ALPS显示与NPH的临床终点相关.
结论:
- DTI-ALPS指数是NPH诊断的一个有希望的非侵入性标记.
- DTI-ALPS可能有助于预测NPH的治疗反应和疾病进展.
- 需要在更大,更多样化的队列中进一步验证.
相关概念视频
01:14Increased Intracranial Pressure l: Introduction
27
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component...
27
01:29Increased Intracranial Pressure ll: Pathophysiology
20
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
20