疲劳与患有炎症性肠病患者的抑郁症状密切相关
Robin Mona1, Andreas Göldi1, Tobias Schneider1
1Department of Gastroenterology and Hepatology, University Digestive Health Care Center, Clarunis, Basel, Switzerland.
Inflammatory intestinal diseases
|May 8, 2025
概括
超过一半的炎症性肠病 (IBD) 患者经历了显著的疲劳,影响了他们的生活质量. 疲劳与这些患者的抑郁症状和年轻年龄密切相关.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 患者的治疗结果.
背景情况:
- 疲劳是一种常见的,但尚未研究的,炎症性肠病 (IBD) 的肠外表现.
- 了解IBD患者的疲劳患病率和相关因素对于改善患者护理至关重要.
研究的目的:
- 为了确定IBD患者临床意义上的疲劳的患病率.
- 为了确定与克罗恩病 (CD) 和性结肠炎 (UC) 患者的疲劳相关的因素.
主要方法:
- 对216名IBD患者进行前性观察性研究,这些患者接受了infliximab或vedolizumab.
- 使用视觉模拟尺度 (VAS-F ≥4) 评估疲劳.
- 评估抑郁症状 (PHQ-8),疾病控制 (IBD-control-8) 和生活质量 (FIS).
主要成果:
- 53.2%的IBD患者报告了临床上有意义的疲劳,UC (63.0%) 高于CD (47.4%).
- 疾病活动与CD中的疲劳相关,但不是UC.
- 疲劳与抑郁症状密切相关 (90.9%的PHQ-8患者≥10),年龄较小,使用精神活性药物,主观疾病控制较低.
结论:
- 疲劳非常普遍,影响IBD患者治疗infliximab或vedolizumab的生命质量.
- 疲劳和抑郁症状之间的强烈关联需要对抑郁症进行监测和明智地使用精神活性药物.
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