蒸发的N,N-Dimethyltryptamine的抗抑郁作用:治疗耐药抑郁症的开放试验试验
Marcelo Falchi-Carvalho1,2, Handersson Barros1,3, Raynara Bolcont1
1Center for Advanced Medical Psychedelics (CAMP), Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
Psychedelic medicine (New Rochelle, N.Y.)
|May 8, 2025
概括
蒸发的N,N-二甲基三胺 (DMT) 在治疗耐药抑郁症患者中显示出快速和持续的抗抑郁作用. 这项研究强调了DMT.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学 是一个学科.
背景情况:
- N,N-Dimethyltryptamine (DMT) 是一种在阿雅华斯卡中发现的迷幻胺,以其潜在的抗抑郁药物特性而闻名.
- 耐治疗抑郁症 (TRD) 仍然是一个重大的临床挑战,有效的治疗选择有限.
研究的目的:
- 调查蒸发的DMT作为治疗耐治疗抑郁症患者的新疗法的疗效.
- 在TRD的剂量升级研究中评估蒸发的DMT的安全性和耐受性.
主要方法:
- 一个开放标签,固定的顺序,剂量升级研究,涉及六名TRD患者.
- 患者在一次会议中接受了两剂蒸发的DMT (15 mg和60 mg).
- 抑郁症的严重程度使用蒙哥马利-阿斯伯格抑郁症评分表 (MADRS) 和患者健康问卷-9 (PHQ-9) 评估,用药后长达一个月.
主要成果:
- 从基线到剂后一个月观察到MADRS和PHQ-9得分的显著降低.
- 到第7天,83.33%的患者表现出反应,66.67%的患者实现了缓解.
- 一个月后,持续反应和缓解率分别为66.67%和50%.
结论:
- 蒸发的DMT在TRD患者中表现出迅速开始和持续的抗抑郁作用.
- 非侵入性施用和短暂的作用时间为幻觉辅助疗法提供了实际优势.
- 在干预精神病学中,DMT显示出作为快速起作用的抗抑郁药的前景.
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