在双相II型疾病中治疗抗抑郁症的psilocybin辅助心理治疗
Shakila Meshkat1,2, Erica Kaczmarek1,2,3, Zoe Doyle1,2
1University of Toronto, Toronto, Canada.
Psychedelic medicine (New Rochelle, N.Y.)
|May 8, 2025
概括
псилоцибин显示出治疗双相二极性障碍抑郁症的潜力,在一项小型试验中观察到显著的症状减少. 没有出现躁狂或精神病,这表明这个患者群体的安全概况有利.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 二极性II型障碍 (BD-II) 经常涉及慢性,耐治疗的抑郁症.
- пси洛西宾表现出快速抗抑郁作用,但其在双极性抑郁症中的疗效尚未研究.
- 这项研究是对治疗耐药性抑郁症 (TRD) 的更大试验的子组分析.
研究的目的:
- 在BD-II患者中初步评估psilocybin治疗双极性抑郁症的安全性和有效性.
- 为了探索psilocybin对治疗耐药人群的抑郁症状的影响.
- 为了评估潜在的风险,如BD-II中与psilocybin相关的躁狂或精神病.
主要方法:
- 包括TRD和BD-II的成年人,不包括精神病患者.
- 服用一次或两次25毫克西治疗.
- 集成的psilocybin会话与准备和整合性心理治疗.
主要成果:
- 包括4名参与者 (平均年龄37.5岁).
- 平均MADRS得分从基线时的32.5下降到剂后第二周的20.3,第二剂后的19分.
- 抑郁症状在6个月后仍然有所改善 (MADRS 21.3),没有出现躁狂,低躁狂或精神病 (YMRS在1时稳定).
结论:
- 西可以改善BD-II患者的抑郁症状.
- 需要进一步研究更大的样本大小来确认这些抗抑郁药效应.
- 在这项初步研究中,psilocybin在治疗双极性抑郁症方面似乎是安全的.
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