饮食炎症指数和便秘之间的非线性关系:从NHANES (2005-2010年) 和孟德尔随机化分析的门识别和见解
Shuxun Wei1, Jin Qian1, Minghao Zou1
1The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Navy Medical University, Shanghai, China.
更高的饮食炎症指数 (DII) 与便秘风险增加有关. 这项研究发现了一种非线性关系,表明饮食改变可以帮助预防便秘.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 便秘是一个日益严重的全球健康问题.
- 传统的治疗方法有其局限性.
- 饮食调整提供了一个方便的治疗方法.
研究的目的:
- 探索饮食炎症指数 (DII) 与便秘之间的关联.
- 确定潜在的饮食策略,以预防和治疗便秘.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2005-2010).
- 通过使用肠道排便频率和便特征来评估便秘.
- 从24小时的饮食回忆数据计算DII.
- 采用回归模型,治疗权重的逆概率 (IPTW),受限立方线 (RCS) 和孟德尔随机化.
主要成果:
- 较高的DII分数与便秘风险增加相关 (OR2.85在Q4与Q1).
- 观察到一种非线性关系,值DII为0.974.
- 性别,收入和糖尿病状况改变了DII-便秘的关联.
结论:
- 在DII和便秘风险之间存在非线性关系,具有特定的值.
- 饮食的炎症潜力在人口和健康群体之间不同地影响便秘风险.
- DII可以为便秘预防和干预策略提供信息.
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