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Michaelia D Cucci¹, Matthew Palmer, Carli Bower

¹Author Affiliations: Department of Pharmacy, Cleveland Clinic Akron General (Drs Cucci, Palmer, and Bower); Department of General Surgery, Cleveland Clinic Akron General (Drs Siddiqui and Vazquez); and Department of Health Sciences, Cleveland Clinic Akron General, Akron, Ohio (Dr Krizo).

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概括

在创伤患者中早期使用血管压缩剂并没有改善无血管压缩剂的日子. 这项研究表明没有显著的益处,但由于样本规模较小,需要进一步调查.

科学领域:

创伤重症监护中心的重症监护中心.
复苏药物是一种复苏药物.
药理学药理学是指药理学的学科.

背景情况:

出血性休克管理包括血流控制,血液替代,以及潜在的输液血管压缩剂.
早期的血管压素使用显示出潜在的益处,但临床效用证据有限.
在创伤患者中,耐火性出血性休克需要有效的治疗策略.

研究的目的:

为了评估早期输血压素在成年创伤患者经历耐火性出血休克的疗效.
为了在治疗严重出血性休克时比较血压素与诺阿基因林.
评估早期血管压素对患者结局和资源利用的影响.

主要方法:

追溯队列研究设计,涉及需要血液制品的成年创伤患者.
主要结局:28天活着和没有血管压缩剂的日子.
二次结局:使用血液制品,无呼吸器日,重症监护室 (ICU) 和住院时间 (LOS),以及安全结局,包括脏替代疗法,静脉血栓塞栓症和液体过载.

主要成果:

这项研究包括37名患者:7人接受了血压素,30人接受了北上腺素.
在主要结局 (28天活着和无血管压缩剂日) 中,两组之间没有发现显著差异.
与上腺素组 (13天) 相比,上腺素组 (20天) 的住院时间 (LOS) 较长.

结论:

早期对受创患者进行血管压缩剂的治疗,这些患者患有耐火性出血性休克,在28天的生存期和无血管压缩剂的日子里没有显著改善.
该研究的小样本规模限制了最终结论,突出了需要更大规模的前性试验的需要.
需要进一步的研究来澄清血管压素在治疗严重出血性休克时的作用和最佳使用.

关键词:

关键的护理关键的护理血流性休克是一个令人震惊的现象.上腺素 (Norepinephrine) 是一种可以创伤是一种创伤.血管压缩中的血管压力.血管压缩器血管压缩器

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