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Updated: May 12, 2025

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
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Direct Reprogramming of Mouse Fibroblasts into Melanocytes

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治疗白风:一个有希望的未来

Jose L López-Estebaranz1, Elena García-Zamora2, Joseph S Griffiths-Acha2

  • 1Dermatology Department, Fundación Alcorcón University Hospital, Madrid, Spain - jlestebaranz@salud.madrid.org.

Italian journal of dermatology and venereology
|May 8, 2025
PubMed
概括

Vitiligo 治疗方法正在进步,Janus 激酶 (JAK) 抑制剂对广泛的疾病显示出有前途. 组合疗法和新生物药物是持续再生色素和预防白风复发的关键.

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Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System07:04

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Skin Cancer

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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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