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衰老,耐力训练和脱皮对骨肌肉内天生的免疫信号传递的影响

Priyanka Khemraj¹, Anastasiya Kuznyetsova¹, David A Hood¹

¹Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario, M3J 1P3, Canada.

Journal of applied physiology (Bethesda, Md. : 1985)

|May 8, 2025

概括

耐力运动可以对抗与年龄相关的骨肌炎症和线粒体功能障碍. 慢性训练通过减少炎症标志物,改善肌肉质量,呼吸和性能,即使在老年小鼠中也是如此.

科学领域:

骨肌肉生理学骨肌肉生理学
线粒体生物学线粒体生物学
这是天生的免疫力.

背景情况:

骨肌的功能依赖于线粒体的能量和适应性.
NLRP3炎症酶对线粒体损伤做出反应,但其在肌肉中的作用尚不清楚.
衰老和不再使用 (缺血) 影响肌肉健康和免疫信号.

研究的目的:

在衰老,耐力训练和化过程中研究骨肌中的免疫信号和线粒体功能.
描述线粒体功能障碍与NLRP3炎症酶激活之间的关系.
评估耐力训练对与年龄相关的肌肉炎症的影响.

主要方法:

研究了接受久坐或耐力训练方案的年轻和老年小鼠.
通过脱皮诱导的停止使用,以评估肌肉质量,线粒体含量和呼吸.
分析了炎症标记物的蛋白质表达 (NLRP3,caspase-1,STING),亡蛋白 (BAX,AIF) 和线粒体DNA (mtDNA).

主要成果:

化减少了肌肉质量,线粒体功能,并增加了炎症和亡标志物.
老化增加了肌肉中的炎症和亡蛋白质.
耐力训练减轻了BAX,NLRP3,caspase-1,STING和GSDMD与年龄相关的增加,从而保持肌肉质量和改善功能.

结论:

废弃的条件,如衰老和化促进骨肌肉炎症和线粒体功能障碍.
慢性耐力训练表现出抗炎作用,抵消与年龄有关的肌肉衰退.
运动是一种有前途的治疗策略,可以缓解与年龄相关的肌肉炎症和功能障碍.

关键词:

在 NLRP3 炎症酶体中,NLRP3 炎症酶体是运动就是炼身体.线粒体中的线粒体.线粒体生物发生是线粒体生物发生.肌肉的不使用.

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