综合性睡眠管理:从分子途径到传统和草药治疗
Yasmina M Ebrahim1, Mohamed A Sadek1,2, Miral O Sabry3
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Naunyn-Schmiedeberg's archives of pharmacology
|May 8, 2025
概括
营养药品为治疗睡眠障碍提供了一种安全有效的替代方案. 这些来自食物的天然化合物有望改善睡眠质量,而不会产生传统药物的副作用.
科学领域:
- 综合医学是一个整体医学.
- 营养科学 营养科学
- 睡眠医学 睡眠医学
背景情况:
- 睡眠对整体健康,情绪和任务效率至关重要.
- 睡眠障碍很普遍,并受到遗传和环境因素的影响.
- 睡眠障碍的传统治疗通常涉及具有戒断效应的习惯形成药物.
研究的目的:
- 审查营养药物作为睡眠障碍的潜在治疗剂.
- 突出自然睡眠辅助剂的益处和作用机制.
- 解决对传统睡眠药物的更安全替代品的需求.
主要方法:
- 在多个科学数据库 (Google Scholar,Elsevier,Springer Nature,Wiley,PubMed,EKB) 中进行了全面的文献搜索.
- 审查的重点是确定和分析用于治疗各种睡眠障碍的营养药研究.
- 评估了被选中的天然化合物的有效性和作用机制.
主要成果:
- 一些营养药物,包括Artemisia annua,白,迷香,朱,激情花,香,阿什瓦甘达,卡瓦卡瓦,衣草和香,在睡眠障碍方面具有显著的益处.
- 这些天然疗法通过调节神经递质和激素通路,减少压力,炎症和氧化应激作用.
- 临床研究支持这些天然睡眠辅助剂的有效性.
结论:
- 营养药物是一种非有毒的,不形成习惯的,有效的选择来治疗睡眠障碍.
- 需要进一步的研究,以充分阐明自然产品影响睡眠的确切机制.
- 自然睡眠辅助剂为改善睡眠质量和解决当前治疗方法的局限性提供了一个有希望的途径.
更多相关视频
相关概念视频
Management of Insomnia
207
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
207
Sedatives and Hypnotics Drugs: Miscellaneous Agents
119
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
119
Sedatives and Hypnotics: Overview
225
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
225
Insomnia
75
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
Multiple factors contribute...
75
Understanding Sleep
199
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
199
Nightmares and Night Terrors
66
Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares...
Nightmares...
66


