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轻度认知障碍与尿素代谢物对灰质的影响有关,在末期病中,结构性变化与末期病有关

Huijie Yuan¹, Zhaoyao Luo¹, Jing Yang¹

¹Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, West Yanta Road, Shaanxi, 710061, Xi'an, China.

Brain imaging and behavior

|May 8, 2025

概括

在左圈灰质体积 (GMV) 的减少与末期病 (ESKD) 的认知障碍有关. 这些GMV变化有效地识别ESKD患者的轻度认知障碍 (MCI).

科学领域:

神经科学是一个神经科学.
腎臟病學 (nephrology) 是一種醫學專業.
放射学放射学是一门学科.

背景情况:

末期病 (ESKD) 与认知功能障碍有关.
轻度认知障碍 (MCI) 在ESKD患者中很普遍.
尿素毒素和结构性大脑变化与ESKD相关的认知衰退有关.

研究的目的:

调查ESKD患有MCI (ESKD-MCI) 的ESKD患者的灰质体积 (GMV) 变化和尿液代谢物.
检查ESKD-MCI的GMV变化和临床特征的分类和诊断疗效.
确定转基因病毒变化在临床风险因素和MCI之间的关联中扮演的调解角色.

主要方法:

结构性MRI扫描和蒙特利尔认知评估 (MoCA) 对65名ESKD患者 (34名ESKD-MCI,31名ESKD-NCI) 和55名健康对照 (HC) 进行.
在三组中分析了灰质体积 (GMV) 差异.
调解分析和支持向量机 (SVM) 用于评估关系和诊断疗效.

主要成果:

与HC相比,ESKD两组都显示出广泛的结构性脑损伤.
与ESKD-NCI患者相比,ESKD-MCI患者在左侧中部和下部旋中表现出降低的GMV.
转基因病毒变化完全介导了血清对MCI的影响,成像特征显示了ESKD-MCI的良好诊断疗效.

结论:

左旋是ESKD-MCI中的一个关键区域,介导尿素代谢物和认知障碍之间的联系.
转基因病毒变化是检测ESKD患者MCI的重要生物标志物.
结构性MRI发现为ESKD认知障碍的早期检测和管理提供了有希望的方法.

关键词:

最终阶段的脏疾病.轻度认知障碍轻度认知障碍结构磁共振成像技术结构磁共振成像技术尿路中的代谢物.

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