相关实验视频
Updated: May 12, 2025

10:42
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
Published on: February 27, 2019
9.3K
癌症PPD2:一种更新的抗癌和蛋白质存储库
Milind Chauhan1, Amisha Gupta1, Ritu Tomer1
1Department of Computational Biology, Indraprastha Institute of Information Technology, Okhla Phase 3, New Delhi 110020, India.
概括
癌症PPD2是抗癌和蛋白质的增强数据库,提供6521条条目的全面数据. 这个更新的资源通过提供详细的信息和针对抗癌剂的先进搜索工具来帮助癌症研究.
科学领域:
- 生物化学 生物化学
- 生物信息学是一种生物信息学.
- 在瘤学瘤学.
背景情况:
- 抗癌和蛋白质在癌症治疗中至关重要.
- 现有的数据库可能缺乏关于这些药物的全面和最新信息.
- 对于抗癌和蛋白质数据的集中,详细的存储库的需求是显而易见的.
研究的目的:
- 为了介绍CancerPPD2,这是CancerPPD数据库的更新和扩展版本.
- 为抗癌和蛋白质提供全面的资源,包括它们的起源,序列,结构和活性.
- 通过综合数据检索和分析工具,促进癌症研究.
主要方法:
- 关于抗癌和蛋白质的6521条目汇编.
- 包括关于天然,化学修饰和终端修饰的数据.
- 从蛋白质数据库 (PDB) 和预测工具 (PEPstrMOD,I-TASSER,AlphaFold) 的结构数据的整合.
- 将条目链接到临床研究和其他数据库 (Uniprot,DrugBank,ThPDB2).
- 开发一个用于程序数据访问的REST API.
主要成果:
- 癌症PPD2包含6521条条目,大大扩展了它的前身.
- 数据包括对392个癌细胞系和28个癌症相关组织进行测试的.
- 包括781个化学修饰和3018个N-/C-终端修饰的抗癌条目.
- 提供了47项临床研究和临床试验的交叉引用.
- 集成了增强的数据检索和相似性搜索工具,以及一个REST API.
结论:
- 癌症PPD2作为一种有价值的,全面的抗癌和蛋白质资源.
- 该数据库支持研究人员识别和分析潜在的抗癌剂.
- 集成工具和API促进了先进的数据挖掘和癌症药物发现中的应用.
更多相关视频
相关概念视频
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Conservation of Protein Domains Over Different Proteins
10.6K
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
10.6K
Leaky Scanning
5.0K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.0K
Abnormal Proliferation
4.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.3K
The Proteasome
8.3K
Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
8.3K

